The miR-1-NOTCH3-Asef Pathway Is Important for Colorectal Tumor Cell Migration
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منابع مشابه
The miR-1-NOTCH3-Asef Pathway Is Important for Colorectal Tumor Cell Migration
The tumor suppressor adenomatous polyposis coli (APC) is mutated in sporadic and familial colorectal tumors. APC stimulates the activity of the Cdc42- and Rac1-specific guanine nucleotide exchange factor Asef and promotes the migration and invasion of colorectal tumor cells. Furthermore, Asef is overexpressed in colorectal tumors and is required for colorectal tumorigenesis. It is also known th...
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Colorectal cancer (CRC) is the most common cancer diagnosed worldwide, and the development of metastases is a major cause of mortality. Accumulating evidence suggests that microRNAs are important in carcinogenesis by affecting the expression of genes that regulate cancer progression. A number of studies have shown that miR-206 is frequently downregulated in many human malignancies, including CR...
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The attached comments indicate obvious scientific merits of your study but also point to some current weaknesses that should be addressed during major revisions. As you will see, the demands expressed from the referees vary significantly. I thus urge you to focus on the most critical experimentation that, as far as I can see center around better support for the functional and crucial contributi...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0080609